/* ============================================================
   Avagene Therapeutics — site styles
   Editorial scientific aesthetic
   ============================================================ */

:root {
  /* color tokens */
  --ink:        #0B1E3F;   /* deep Prussian navy — primary */
  --ink-soft:   #27364F;   /* secondary ink */
  --mute:       #5A6072;   /* muted body / meta */
  --rule:       #D9D2C2;   /* subtle editorial rule */
  --canvas:     #FAF7F2;   /* warm ivory page */
  --card:       #FFFFFF;
  --accent:     #C75A4B;   /* restrained coral — used sparingly */
  --accent-dk:  #A04538;
  --good:       #3D6B57;   /* muted forest for success / compliance */

  /* typography */
  --serif: "Fraunces", "Newsreader", Georgia, "Times New Roman", serif;
  --sans:  "IBM Plex Sans", -apple-system, BlinkMacSystemFont, "Helvetica Neue", Arial, sans-serif;
  --mono:  "IBM Plex Mono", ui-monospace, SFMono-Regular, Menlo, monospace;

  /* layout */
  --edge: clamp(1.25rem, 4vw, 3.5rem);
  --max: 1180px;
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  background: var(--canvas);
  color: var(--ink);
  font-family: var(--sans);
  font-size: 17px;
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
  text-rendering: optimizeLegibility;
}

/* ---------- typography ---------- */
h1, h2, h3, h4 {
  font-family: var(--serif);
  font-weight: 500;
  letter-spacing: -0.015em;
  color: var(--ink);
  margin: 0 0 0.5em;
  font-variation-settings: "opsz" 24, "SOFT" 30;
}

h1 { font-size: clamp(2.4rem, 5.2vw, 4.2rem); line-height: 1.02; letter-spacing: -0.03em; }
h2 { font-size: clamp(1.75rem, 3.4vw, 2.6rem); line-height: 1.1; }
h3 { font-size: 1.4rem; line-height: 1.3; }
h4 { font-size: 1.05rem; font-family: var(--sans); font-weight: 600; letter-spacing: 0.02em; text-transform: uppercase; }

p { margin: 0 0 1em; max-width: 68ch; }
strong { font-weight: 600; color: var(--ink); }
em { font-style: italic; }

a {
  color: var(--ink);
  text-decoration: none;
  border-bottom: 1px solid var(--rule);
  transition: border-color 0.15s ease, color 0.15s ease;
}
a:hover { border-color: var(--accent); color: var(--accent); }

.eyebrow {
  font-family: var(--mono);
  font-size: 0.78rem;
  text-transform: uppercase;
  letter-spacing: 0.14em;
  color: var(--accent);
  margin-bottom: 1.2rem;
  display: inline-block;
}

.eyebrow.muted { color: var(--mute); }

hr.rule {
  border: 0;
  border-top: 1px solid var(--rule);
  margin: 3rem 0;
}

hr.rule-thick {
  border: 0;
  border-top: 2px solid var(--ink);
  margin: 2rem 0;
  width: 3rem;
}

/* ---------- layout ---------- */
.wrap {
  max-width: var(--max);
  margin: 0 auto;
  padding: 0 var(--edge);
}

section { padding: clamp(3rem, 7vw, 6rem) 0; }

/* ---------- header / nav ---------- */
.site-header {
  padding: 1.4rem 0;
  border-bottom: 1px solid var(--rule);
  position: sticky;
  top: 0;
  background: rgba(250, 247, 242, 0.92);
  backdrop-filter: saturate(140%) blur(8px);
  -webkit-backdrop-filter: saturate(140%) blur(8px);
  z-index: 40;
}

.site-header .wrap {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 2rem;
}

.brand {
  display: flex;
  align-items: center;
  gap: 0.7rem;
  border: 0;
  font-family: var(--serif);
  font-size: 1.35rem;
  font-weight: 500;
  letter-spacing: -0.01em;
  color: var(--ink);
}
.brand:hover { color: var(--ink); }

.brand-mark {
  width: 28px;
  height: 28px;
  display: inline-block;
}

.brand-suffix {
  font-family: var(--mono);
  font-size: 0.68rem;
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--mute);
  align-self: center;
  padding-left: 0.7rem;
  border-left: 1px solid var(--rule);
  margin-left: 0.1rem;
}

nav.primary {
  display: flex;
  gap: 2rem;
  align-items: center;
}
nav.primary a {
  border: 0;
  font-size: 0.92rem;
  color: var(--ink-soft);
  font-weight: 500;
}
nav.primary a:hover { color: var(--accent); }
nav.primary a.current { color: var(--accent); }

@media (max-width: 720px) {
  nav.primary { gap: 1.1rem; }
  nav.primary a { font-size: 0.85rem; }
  .brand-suffix { display: none; }
}

/* ---------- hero ---------- */
.hero {
  padding: clamp(4rem, 10vw, 9rem) 0 clamp(3rem, 7vw, 6rem);
  position: relative;
  overflow: hidden;
}

.hero-grid {
  display: grid;
  grid-template-columns: 1.3fr 1fr;
  gap: clamp(2rem, 6vw, 6rem);
  align-items: start;
}

@media (max-width: 900px) {
  .hero-grid { grid-template-columns: 1fr; }
}

.hero h1 .accent { color: var(--accent); font-style: italic; }

.hero-lede {
  font-family: var(--serif);
  font-size: clamp(1.1rem, 1.6vw, 1.35rem);
  line-height: 1.45;
  color: var(--ink-soft);
  max-width: 38ch;
  margin-top: 1.5rem;
  font-weight: 400;
}

.hero-meta {
  margin-top: 2.5rem;
  padding: 1.5rem;
  border: 1px solid var(--rule);
  background: var(--card);
  font-size: 0.92rem;
}
.hero-meta dt {
  font-family: var(--mono);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.12em;
  color: var(--mute);
  margin-bottom: 0.25rem;
}
.hero-meta dd {
  margin: 0 0 1.1rem;
  color: var(--ink);
}
.hero-meta dd:last-child { margin-bottom: 0; }

/* ---------- cards & sections ---------- */
.two-col {
  display: grid;
  grid-template-columns: 1fr 2fr;
  gap: clamp(2rem, 5vw, 4.5rem);
  align-items: start;
}
@media (max-width: 800px) {
  .two-col { grid-template-columns: 1fr; gap: 1rem; }
}

.section-label {
  font-family: var(--mono);
  font-size: 0.78rem;
  text-transform: uppercase;
  letter-spacing: 0.14em;
  color: var(--mute);
}

.cards {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
  gap: 1.25rem;
  margin-top: 2rem;
}

.card {
  padding: 1.8rem;
  border: 1px solid var(--rule);
  background: var(--card);
}
.card h3 { font-size: 1.15rem; margin-bottom: 0.6rem; }
.card p { font-size: 0.95rem; color: var(--ink-soft); margin-bottom: 0; }
.card .num {
  font-family: var(--mono);
  font-size: 0.75rem;
  letter-spacing: 0.1em;
  color: var(--accent);
  display: block;
  margin-bottom: 1rem;
}

/* ---------- CTA / buttons ---------- */
.cta-row {
  display: flex;
  flex-wrap: wrap;
  gap: 0.9rem;
  margin-top: 2rem;
}

.btn {
  display: inline-block;
  padding: 0.85rem 1.4rem;
  font-family: var(--sans);
  font-size: 0.95rem;
  font-weight: 500;
  border: 1px solid var(--ink);
  background: var(--ink);
  color: var(--canvas);
  border-bottom: 1px solid var(--ink);
  transition: background 0.18s ease, color 0.18s ease;
}
.btn:hover {
  background: var(--accent);
  color: var(--canvas);
  border-color: var(--accent);
}

.btn.ghost {
  background: transparent;
  color: var(--ink);
  border-color: var(--ink);
}
.btn.ghost:hover {
  background: var(--ink);
  color: var(--canvas);
}

/* ---------- partners strip ---------- */
.partners {
  border-top: 1px solid var(--rule);
  border-bottom: 1px solid var(--rule);
  padding: 2rem 0;
  margin-top: 3rem;
}
.partners .label {
  font-family: var(--mono);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.14em;
  color: var(--mute);
  margin-bottom: 1.2rem;
  display: block;
}
.partners-list {
  display: flex;
  flex-wrap: wrap;
  gap: 2rem 2.5rem;
  font-family: var(--serif);
  font-size: 1.05rem;
  color: var(--ink-soft);
  align-items: center;
}
.partners-list span { white-space: nowrap; }

/* ---------- policy / long-form pages ---------- */
.doc {
  max-width: 760px;
  margin: 0 auto;
  padding: clamp(3rem, 7vw, 5rem) var(--edge);
}

.doc .meta {
  font-family: var(--mono);
  font-size: 0.78rem;
  color: var(--mute);
  text-transform: uppercase;
  letter-spacing: 0.1em;
  margin-bottom: 1rem;
}

.doc h1 { font-size: clamp(2rem, 4vw, 3rem); margin-bottom: 0.3em; }
.doc .subtitle {
  font-family: var(--serif);
  font-style: italic;
  font-size: 1.15rem;
  color: var(--ink-soft);
  margin-bottom: 2rem;
}

.doc h2 {
  font-size: 1.5rem;
  margin-top: 2.8rem;
  margin-bottom: 0.5rem;
  padding-top: 1.2rem;
  border-top: 1px solid var(--rule);
}
.doc h2:first-of-type { border-top: 0; padding-top: 0; margin-top: 2rem; }

.doc h3 {
  font-family: var(--sans);
  font-size: 0.95rem;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  font-weight: 600;
  margin-top: 2rem;
  color: var(--ink-soft);
}

.doc p, .doc li { font-size: 1rem; line-height: 1.7; color: var(--ink-soft); }
.doc li { margin-bottom: 0.4rem; }

.doc .callout {
  border-left: 3px solid var(--accent);
  padding: 0.2rem 0 0.2rem 1.2rem;
  margin: 1.5rem 0;
  font-size: 0.95rem;
  color: var(--ink-soft);
}

.doc .draft-banner {
  background: #FFF4EC;
  border: 1px solid #E8B9A8;
  padding: 1rem 1.2rem;
  margin: 0 0 2.5rem;
  font-size: 0.9rem;
  color: var(--accent-dk);
}

.doc .sig-block {
  margin-top: 3rem;
  padding-top: 2rem;
  border-top: 1px solid var(--rule);
  font-size: 0.95rem;
  color: var(--ink-soft);
}
.doc .sig-block .sig-line {
  display: inline-block;
  border-bottom: 1px solid var(--ink);
  width: 260px;
  margin-bottom: 0.3rem;
}

/* ---------- footer ---------- */
footer.site-footer {
  border-top: 1px solid var(--rule);
  padding: 3rem 0 2rem;
  margin-top: 4rem;
  font-size: 0.88rem;
  color: var(--mute);
}
footer.site-footer .wrap {
  display: grid;
  grid-template-columns: 1.5fr 1fr 1fr 1fr;
  gap: 2rem;
}
@media (max-width: 780px) {
  footer.site-footer .wrap { grid-template-columns: 1fr 1fr; }
}
footer.site-footer h4 {
  font-family: var(--mono);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.14em;
  color: var(--ink);
  margin-bottom: 0.9rem;
}
footer.site-footer a {
  display: block;
  border: 0;
  color: var(--mute);
  padding: 0.2rem 0;
}
footer.site-footer a:hover { color: var(--accent); }
footer.site-footer .bottom {
  grid-column: 1 / -1;
  border-top: 1px solid var(--rule);
  padding-top: 1.2rem;
  margin-top: 1rem;
  display: flex;
  justify-content: space-between;
  flex-wrap: wrap;
  gap: 1rem;
  font-family: var(--mono);
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.1em;
}

/* ---------- decorative element: subtle roller bottle motif ---------- */
.hero-motif {
  position: absolute;
  top: 0;
  right: 0;
  width: min(38vw, 420px);
  height: 100%;
  opacity: 0.07;
  pointer-events: none;
  z-index: 0;
}

.hero > .wrap { position: relative; z-index: 1; }

/* ---------- compliance page specific ---------- */
.compliance-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
  margin: 2rem 0;
}
@media (max-width: 700px) {
  .compliance-grid { grid-template-columns: 1fr; }
}
.compliance-grid .item {
  padding: 1.2rem;
  border: 1px solid var(--rule);
  background: var(--card);
  font-size: 0.92rem;
}
.compliance-grid .item .label {
  font-family: var(--mono);
  font-size: 0.7rem;
  letter-spacing: 0.12em;
  text-transform: uppercase;
  color: var(--accent);
  display: block;
  margin-bottom: 0.4rem;
}